Thursday, November 09, 2006

 

Having Your Cake And Eating It Too

Boston (USA), 08 November: Treating middle-aged mice fed a high-calorie diet with a compound found in red wine improves their health and extends lifespan, a paper published online this week in Nature reports.

David Sinclair and colleagues fed mice high-calorie diets supplemented with resveratrol, a small molecule that has been shown to extend the life spans of various animals. The treatment shifted the animals' physiology towards that of mice fed a standard diet. They lived longer than mice on the same high-fat diet without resveratrol, and even though they didn't lose any weight, their quality of life was also improved– resveratrol-treated mice had healthier livers and better motor coordination.

Resveratrol seems to counter various of the health risks associated with a high-fat diet, but without skimping on the calories. When scaled up, the doses used in the mouse study should be feasible for human consumption, but it's not yet clear whether the molecule will yield similar effects in people. If it does, it may lead to the development of drugs that can reduce some of the negative consequences of excess calorie intake and improve health and survival.

(ResearchSEA)

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