Wednesday, November 08, 2006
Mechanisms Involved In Outbreaks Of Adult T-cell Leukemia Identified
Tokyo (Japan), 07 November: A research group headed by Takashi Tsuji of Tokyo University of Science's Tissue Engineering Research Center identified mechanisms behind outbreaks of adult T-cell leukemia.
A research group headed by Takashi Tsuji of the Tokyo University of Science's Tissue Engineering Research Center identified mechanisms behind outbreaks of adult T-cell leukemia. This research was pursued in collaboration with Yoshi Utsunomiya from Foundation Jiaikai Imamura Bun-in Hospital and Katsuhiko Ito from Kyoto University and other researchers. The results of this research are expected to lead to the development of new treatments for adult T-cell leukemia.
Adult T-cell leukemia/lymphoma (ATLL) has been characterized as one of the most aggressive human neoplasias and its incidence is thought to be caused by both genetic and epigenetic alterations to the host cellular genes of T-cells infected with human T-cell leukemia virus type I (HTLV-I). A multilobulated nuclear appearance is an important diagnostic marker of ATLL and we have now identified that the molecular mechanisms underlying these formations occur through microtubule rearrangement via PI3-kinase activation by AILIM/ICOS-signaling.
(ResearchSEA)
A research group headed by Takashi Tsuji of the Tokyo University of Science's Tissue Engineering Research Center identified mechanisms behind outbreaks of adult T-cell leukemia. This research was pursued in collaboration with Yoshi Utsunomiya from Foundation Jiaikai Imamura Bun-in Hospital and Katsuhiko Ito from Kyoto University and other researchers. The results of this research are expected to lead to the development of new treatments for adult T-cell leukemia.
Adult T-cell leukemia/lymphoma (ATLL) has been characterized as one of the most aggressive human neoplasias and its incidence is thought to be caused by both genetic and epigenetic alterations to the host cellular genes of T-cells infected with human T-cell leukemia virus type I (HTLV-I). A multilobulated nuclear appearance is an important diagnostic marker of ATLL and we have now identified that the molecular mechanisms underlying these formations occur through microtubule rearrangement via PI3-kinase activation by AILIM/ICOS-signaling.
(ResearchSEA)
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